Background: Recent studies have indicated that monocyte chemoattractant protein-1 (MCP-1) plays an important\nrole in the initiation and progression of ischaemic heart disease. However, no previous research has investigated\nthe correlation between serum MCP-1 levels and early changes in myocardial function in patients with ST-segmental\nelevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI).\nMethods: A total of 87 STEMI patients who had undergone a successful primary PCI were consecutively recruited. All\nthe patients included in this study were grouped into two subgroups according to the median value of MCP-1 upon\nadmission. An early change in left ventricular ejection fraction (LVEF) was defined as (LVEF at 3 months post-STEMI)-\n(LVEF at 2 days post-STEMI).\nResults: Serum MCP-1 levels increased gradually over time during the first 72 h after the onset of STEMI. The\nconcentration of hypersensitive cardiac troponin I (hs-cTnI) upon admission as well as at 24 h and 72 h after\nprimary PCI, especially the peak hs-cTnI concentration, declined significantly in the low admission MCP-1\ngroup. As continuous variable, admission MCP-1 also correlated positively with admission hs-cTnI, hs-cTnI at\n24 h after primary PCI, and peak hs-cTnI........................
Loading....